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  1. ; (, microPublication biology)
    null (Ed.)
    Regulation of the essential trace element zinc is necessary to avoid the toxic consequences caused by too little or too much of this metal (Vallee and Falchuk 1993; Rosen 2006). The zinc-response pathway has been extensively studied in the nematode roundworm Caenorhabditis elegans and several genes have been discovered that function to modulate sensitivity to both high and low zinc concentrations (Dietrich et al. 2016). Recently, we identified a quantitative trait locus (QTL) on the center of chromosome V, indicating that natural genetic variation between the laboratory strain, N2, and a genetically divergent wild isolate from Hawaii, CB4856, contributes to differential responses to excess zinc (Evans et al. 2020). 
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